A newarticle published in Seminars in Cancer Biology reported that melanoma cells produce a variety of extracellular vesicle (EV) types – shedding vesicles and exosomes (EXOs). These EVs are defined by their mechanism of cellular production. The authors stated that until now, majority of EV investigations have been centered around melanoma EXOs or small EVs (sEVs). Natural melanoma sEVs mediate pro-tumor processes including angiogenesis, immune regulation and modification of tissue microenvironments, which are interdependent. They collaborate to support tumor growth and survival. Additionally, pro-tumor functions attributed to melanoma cells, are recapitulated through melanoma sEVs, ensuringa certain degree of redundancy within the melanoma pathogenic process. Furthermore, it allows for rapid adaptation of melanoma cells to changing microenvironments, anti-tumor immune responses and therapeutic challenges.It was inferred that as a result of their composition and inherent ability to engage the immune system, natural melanoma EVs possess excellent biomarker potential and might be used therapeutically as tumor vaccines.